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Shreyas Kuddannaya, United States

Post-doctoral research fellow
Radiology-Division of MR research
Institute of Cell Engineering, Johns Hopkins School of Medicine

Shreyas Kuddannaya is a postdoctoral research fellow in the lab of Prof. Jeff Bulte at the Institute for Cell Engineering at Johns Hopkins School of Medicine. His current research involves studying the effects of glial restricted progenitor cell transplantation in the SOD1-G93A mouse model of Amyotrophic lateral sclerosis. From his research expertise in stem cell biology and materials science, he is assessing weather scaffolding the cells in biocompatible hydrogels can enhance the post-transplantation survival in the mouse CNS, mitigate inflammation and differentiate effectively into astrocytes and oligodendrocytes. To validate cell survival and hydrogel degradation in mouse CNS in real-time, he employs high resolution in vivo imaging of both cell survival and hydrogel degradation via bioluminescence imaging and Chemical Exchange Saturation transfer MRI (CEST MRI) respectively. Prior to joining Hopkins, He obtained his Doctoral degree (Ph.D.) in Biomedical Engineering from Nanyang technological University in Singapore and Masters' degree in Biochemical Engineering from Delft University of Technology in the Netherlands. In his future research, he aims to combine key aspects of CNS regeneration, material science and bioimaging to improve the efficacy of stem cell transplantation and improve clinical outputs.